Strong gravitational lensing can reveal the influence of dark-matter substructure in galaxies, but analyzing these effects from noisy, low-resolution images poses a significant challenge. In this work, we propose a masked autoencoder (MAE) pretraining strategy on simulated strong-lensing images from the DeepLense ML4SCI benchmark to learn generalizable representations for two downstream tasks: (i) classifying the underlying dark matter model (cold dark matter, axion-like, or no substructure) and (ii) enhancing low-resolution lensed images via super-resolution. We pretrain a Vision Transformer encoder using a masked image modeling objective, then fine-tune the encoder separately for each task. Our results show that MAE pretraining, when combined with appropriate mask ratio tuning, yields a shared encoder that matches or exceeds a ViT trained from scratch. Specifically, at a 90% mask ratio, the fine-tuned classifier achieves macro AUC of 0.968 and accuracy of 88.65%, compared to the scratch baseline (AUC 0.957, accuracy 82.46%). For super-resolution (16x16 to 64x64), the MAE-pretrained model reconstructs images with PSNR ~33 dB and SSIM 0.961, modestly improving over scratch training. We ablate the MAE mask ratio, revealing a consistent trade-off: higher mask ratios improve classification but slightly degrade reconstruction fidelity. Our findings demonstrate that MAE pretraining on physics-rich simulations provides a flexible, reusable encoder for multiple strong-lensing analysis tasks.

Accurate diagnosis of spitzoid tumors (ST) is critical to ensure a favorable prognosis and to avoid both under- and over-treatment. Epigenetic data, particularly DNA methylation, provide a valuable source of information for this task. However, prior studies assume complete data, an unrealistic setting as methylation profiles frequently contain missing entries due to limited coverage and experimental artifacts. Our work challenges these favorable scenarios and introduces ReMAC, an extension of ReMasker designed to tackle classification tasks on high-dimensional data under complete and incomplete regimes. Evaluation on real clinical data demonstrates that ReMAC achieves strong and robust performance compared to competing classification methods in the stratification of ST. Code is available: https://github.com/roshni-mahtani/ReMAC.

Automatic sleep staging plays a vital role in assessing sleep quality and diagnosing sleep disorders. Most existing methods rely heavily on long and continuous EEG recordings, which poses significant challenges for data acquisition in resource-constrained systems, such as wearable or home-based monitoring systems. In this paper, we propose the task of resource-efficient sleep staging, which aims to reduce the amount of signal collected per sleep epoch while maintaining reliable classification performance. To solve this task, we adopt the masking and prompt learning strategy and propose a novel framework called Mask-A ware Sleep Staging (MASS). Specifically, we design a multi-level masking strategy to promote effective feature modeling under partial and irregular observations. To mitigate the loss of contextual information introduced by masking, we further propose a hierarchical prompt learning mechanism that aggregates unmasked data into a global prompt, serving as a semantic anchor for guiding both patch-level and epoch-level feature modeling. MASS is evaluated on four datasets, demonstrating state-of-the-art performance, especially when the amount of data is very limited. This result highlights its potential for efficient and scalable deployment in real-world low-resource sleep monitoring environments.